Plasticity and the Aging Brain: Projects

All Collaborations 

Plasticity and the Aging Brain

Neuroscience Collaboration

The Simons Collaboration on Plasticity and the Aging Brain (SCPAB) aims to discover mechanisms of resilience and functional maintenance in the aging brain, and to establish a baseline for plasticity-related changes with age across many model systems. The SCPAB’s focus on the basic biology of cognitive aging is foundational to future translational approaches aimed at minimizing cognitive decline and extending healthy lifespan.

Current Projects

blue neuro round graphic with yellow frames

Promoting functional brain maintenance – insights from successful agers

Neural Underpinnings from Sabatini's Aging Brain Project

Brain specific thyroid hormone dysfunction drives age related cognitive changes and movement and cognition as a window on the lifespan

A collage of microscope images showing fluorescent green and magenta neuron structures in a zebrafish brain, highlighting neural networks and synapses in various close-up and wide views.

How does sleep sustain synaptic lipid function across life and protein and lipid homeostasis in the aging brain

Male Human Sex Chromosomes X and Y SEM

Sex-specific differences in cognitive and brain aging

More Collaborations

Fluorescent microscopy image of mouse brain tissue, showing layers of cells in green and purple, highlighting neural structures and cell distribution.

Ecological Neuroscience

Simons Collaboration
Fluorescence microscopy image showing a network of bright green nerve fibers connecting to a cluster of yellow and red cellular structures.

Global Brain

Simons Collaboration